If you or a person you know has recently been diagnosed with seronegative arthritis, you might be wondering what that means. Considering its rare nature, the condition still confuses some people when it comes to signs, causes and potential forms of treatment.

In this article, we give you a summary of everything you need to know about seronegative arthritis.

What Is Seronegative Arthritis?

Seronegative arthritis is a form of rheumatoid arthritis that occurs in people with low levels of CPP antibodies.

To understand seronegative arthritis, one has to understand the basics of rheumatoid arthritis first. To get diagnosed with rheumatoid arthritis, doctors test for the rheumatoid factor and the presence of CPP antibodies in a potential patient’s body.

These antibodies are responsible for attacking the cells of the lining of joints, resulting in inflammation, pain and bone damage. Doctors also consider the signs and symptoms the person expresses over time.

Patients found with high levels of CPP antibodies are considered to have seropositive arthritis, which is the commonest form of rheumatoid arthritis.

 Individuals that test negative for the rheumatoid factor and have low levels may not be considered, but if they still express visible signs of rheumatoid arthritis, they are diagnosed with the second form of rheumatoid arthritis, seronegative arthritis.

In other words, patients with seronegative arthritis are still suffering from rheumatoid arthritis, despite the variation in causative factors. In fact, the low CPP antibodies’ number tends to rise in most seronegative patients after some time, resulting in a change of diagnosis to seropositive arthritis.

Suffering from arthritis? Find out what we can do to solve your problems. Click Here!

The Common Signs Of Seronegative Arthritis

  • Inflammation around the joints
  • Tender joints
  • Joint pain
  • Redness of the skin
  • Stiffness in most joints especially the hands, knees, ankles and hips
  • Morning stiffness
  • Fatigue

Treatment Options

Just like other forms of arthritis, seronegative arthritis and all its symptoms can be treated to complete healing. A number of medications are available over the counter in addition to countless natural remedies, surgical procedures and physiotherapy exercises.

Treatment is done to ease the pain resulting from the inflammation and to stop disease progression where possible. Continue reading below to learn how you can treat seronegative arthritis.

Suffering from arthritis? Find out what we can do to solve your problems. Click Here!


Most doctors prescribe a series of medicines to combat the inflammation in the joints and relieve the pain. Nonsteroidal anti-inflammatory drugs such as celebrex and ibuprofen are commonly used.

In cases where anti-inflammatory drugs are not effective enough, drugs known as disease modifying anti-rheumatic drugs (DMARDs) are prescribed; the commonly recommended drugs usually contain hydrochloroquine and methotrexate, which is a very effective immunosuppressant.

Intra-articular steroid injections may also be used for alternative treatment. They are shot directly into the joint to stop the inflammation.


Surgery is another potential treatment option; it may be carried to replace the lining or replace damaged bones or tissues in the joint with metal or high grade plastic parts.


A series of exercises can be done through physiotherapy to strengthen the body’s joints and create new means of performing daily activities without straining the body’s joints further. The idea is that physiotherapy and exercise can improve mobility, strengthen muscles and reduce pain.


Because seronegative arthritis is still a form of rheumatoid arthritis, proper dieting is essential in combating the disease and its effects. The ideal diet for anyone suffering from seronegative arthritis should include adequate sources of Omega 3 fatty acid, selenium, vitamin C, Vitamin A, anthocyanins, fibre, vitamin D and beta cryptoxathin such as fish, fruits, vegetables, nuts, herbs and essential oils.

Herbal Remedies

Natural herbs are known to be rich in antioxidants, whose effect on inflammation is highly regarded and positive. We recommend that you make use of herbs such as basil, thyme, cumin, green tea, garlic etc. by adding them to our diet or making pastes out of them and applying them to the affected joints.

Ayurvedic Medicine

If you prefer a cheaper and safer form of treatment, Ayurvedic medicine is the treatment option you should consider. It is a combination of natural remedies, mind and body exercises and lifestyle recommendations that you can use to treat any disease without surgery or medication.

Ayurvedic medicine has long been used to treat different forms of arthritis all over India and the world, and that includes rheumatoid arthritis and its seronegative /seropositive forms.

Rangoli Ayurved is a highly regarded Ayurvedic treatment company in India whose experience in treating seronegative arthritis has been moulded by years of treating different patients with different symptoms and healing all of them. Their seronegative arthritis treatment package is one of the most popular treatment options in India. It is comprised of;

  1. Rangoli Jeevan Sudha Special
  2. Rangoli Corni Care
  3. Rangoli Body Oil

All three remedies are effective against all forms of arthritis, and come with a 100% money back guarantee! Check out Rangoli Ayurved’s arthritis treatment package here.

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